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Peritoneal Mesothelioma
Mesothelioma is a form of cancer occurring in many of the body’s tissues. Although most commonly developed in the lungs, other areas of the body have also been known to be affected. Malignant peritoneal mesothelioma (MPM) is a particularly rare form of cancer, seen in only one out of four to five million cases. This disease affects the lining of the abdominal cavity, and is determined to be malignant based on the high degree of invasion.
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Despite its infrequency, peritoneal mesothelioma comprises roughly 25% of all mesothelial cancers. Those most affected are men in their 50’s and 60’s. MPM is hard to diagnose and is associated with a poor prognosis. Researchers at the Taif University College of Medicine have recently published a case study on the disease in hopes of improving diagnosis and treatment options.
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Malignant peritoneal mesothelioma has no disease specific symptoms. Generally, patients experience abdominal pain and stiffness, weight loss, fever, vomiting, and a loss of appetite, all of which are very general characteristics associated with any number of illnesses. These arbitrary symptoms are just what the patient of focus in the Taif University study experienced. The patient was hospitalized for what doctors assumed to be appendicitis – a condition where the appendix becomes inflamed and filled with waste, causing abdominal pain. The patient’s appendix was removed in response to this diagnosis, however, his condition actually worsened as a result. This led doctors to biopsy the appendix and reevaluate the abdominal cavity using laparoscopy.
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Laparoscopy is a minimally invasive procedure that uses a small, lit tube to “see” abdominal organs through an incision, or cut, in the stomach. After examination, it was evident that the lining of the patient’s abdominal cavity was infected with cancer cells, leading doctors to diagnose MPM. Once correctly identified, the primary treatment for MPM is surgery to remove infected areas accompanied by localized chemotherapy. Unfortunately, it is often impossible to completely resect cancerous tumors and even with a moderately early diagnosis, survival rates are low. The rarity of MPM provides obstacles for doctors to determine better methods of treatment.
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The researchers of this study have concluded that the only accurate means of diagnosis of malignant peritoneal mesothelioma is through open surgery with biopsy and/or laparoscopy. However, determining when to use these techniques is difficult based on symptoms alone. Because of this, the condition is often diagnosed too late, rendering treatment futile. From the time of diagnosis, an individual with MPM is expected to live for less than one year. MPM is a lethal disease that is highly under-researched. With their recent case study, the researchers at Taif University hope to draw new attention to the illness and prompt a more efficient method of diagnosis.
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