Mesothelioma Lawyers Michigan - Mesothelioma Lawyers Near Me Michigan


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Mesothelioma Histology
The branch of biology and medicine in which cells and tissues of animals and plants are studied is called histology. Tissue samples are observed under a microscope after being stained and put on a slide in order to study the composition and structure of the cells making up the tissue. Malignant mesothelioma is described as a rare, asbestos-related form of cancer that appears on the thin tissues that cover and protect the lungs and abdomen. Thus, mesothelioma histology is recognized as the study of cancerous mesothelial cells. Mesothelioma histology is considered a segment of histopathology, as histopathology is the study of diseased cells. Mass of tissue, known as tumors, develops when cancer cells multiply instead of dying off. The tumors are the tissue, which are examined under the microscope.


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Histology reports of a biopsy are the only way to determine for sure if someone has mesothelioma or not.  These reports are also incredibly important in determining the mesothelioma cell type. The 3 cell types are epithelioid, sarcomatoid, and biphasic. Because of the information these reports provide, they also help with determining the course of treatment, and inform doctors of what the prognosis is looking like.
Mesothelial cells line three cavities in the body: the pleural cavity, the peritoneal cavity, and the pericardial cavity. These cells produce certain surface proteins, such as glycoproteins, that play a vital role in the function that the endoplasmic reticulum (ER). ER stress occurs when there is an overload of these surface proteins, which is believed to cause several illnesses, including mesothelioma, the cancer of mesothelial cells.


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An experiment was set up in order to investigate the correlation of endoplasmic reticulum (ER) stress and cancer by measuring markers of ER stress in cancerous mesothelial cells. Surface proteins such as ‘CHOP’ were stained and studied. CHOP is a protein that responds to stress in the ER. It was found that the CHOP protein played a role in cell survival, and whether cancerous cells formed.


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When endoplasmic reticulum stress levels increase (due to excess surface protein production) it was found that phosphatase growth in the cell is halted and DNA is damaged. It was observed that DNA damage and phosphatase growth arrest is linked to the degree to which mesothelial cells were mutated.


The findings of the experiment led to the conclusion that CHOP protein staining can provide essential prognostic information that could lead to future breakthroughs in understanding and treating mesothelioma.


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